Monday, 27 June 2016

Smoking may have negative effects on sperm quality

A recent study found that that sperm of men who smoke has a greater extent of DNA damage than that of non-smokers.


Researchers also assessed 422 proteins in participants' sperm. One protein was absent, 27 proteins were underrepresented, and 6 proteins were over-represented in smokers. Analyses of these proteins suggest that cigarette smoking may promote an inflammatory response in the male reproductive tract.

The BJU International study included 20 nonsmoking men and 20 men who smoked.

"More and more studies are demonstrating a harmful effect of smoking on male fertility. Our results point in the direction of important semen alterations: semen of smokers presents an inflammatory nature, associated with decreased capacity of sperm to achieve fertilization and generate a healthy pregnancy," said Dr. Ricardo Pimenta Bertolla, senior author of the study. "It is especially noteworthy that, in our study, sperm DNA fragmentation was increased. Other studies have proposed this to be a potentially promutagenic effect, which is to say that sperm with altered DNA may lead to health problems in the offspring."

Conclusion

In conclusion, cigarette smoking was associated with an inflammatory state in the accessory glands and in the testis, as shown by enriched proteomic pathways. This state causes an alteration in sperm functional quality, which is characterized by decreased acrosome integrity and mitochondrial activity, as well as by increased nuclear DNA fragmentation.

Reference : M. P. Antoniassi, P. Intasqui Lopes, M. Camargo, D. S. Zylbersztejn, V. M. Carvalho, K. H. M. Cardozo, R. P. Bertolla. Analysis of the sperm functional aspects and seminal plasma proteomic profile from male smokers. BJU International, 2016; DOI: 10.1111/bju.13539